George, MulongoJolocam, MbabaziOdongkara, B.Twinomuhwezi, HMpango, G.B.2026-06-172026-06-172011-06-07Mulongo, G., Mbabazi, J., Odongkara, B., Twinomuhwezi, H., & Mpango, G. B. (2011). New biologically active compounds from 1, 3-diketones.2231-606Xhttp://hdl.handle.net/20.500.14270/847The ready availability of cyclohexanones and the enhanced reactivity at their α-positions render them starting materials of choice in the present study. The synthesis of new compounds of antimicrobial activity was undertaken by the coupling of aromatic amines with 5,5-dimethyl cyclohexan-1,3-dione (dimedone). The products were refluxed with N–benzyl-N-phenylhydrazine in acetic acid. The structures of the products were elucidated using micro- and IR-spectral analyses. They were confirmed using 1H NMR at 60MHz and TMS as internal standard. The diketone derivatives were tested for their biological activity against gram-positive Cocci and Bacilli, and gram-negative Bacilli. The study showed that the derivatives gave a wide range of activity from inactive to highly active, which proves it to be of fresh pharmaceutical interest. Key words: Dimedone, Antimicrobial activity, Gram-positive Cocci and Bacilli, Gram-negative BacillienDimedoneAntimicrobial activityGram-positive Cocci and BacilliGram-negative BacilliArticle