Research Articles

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Characteristics of the COVID-19 Patients Treated at Gulu Regional Referral Hospital, Northern Uganda: A Cross-Sectional Study
(Journal of Infectious Diseases & Therapy, 2022) Okot, Christopher; Baguma, Steven; Alema Onira, Nelson; Odong Agings, Willis; Arwinyo, Baifa; Elima, James; Apiyo, Paska; Layet, Paska; Pebalo Pebolo, Francis; Acullu, Denis; Oloya, Johnson Nyeko; Oyat, Freddy Wathum Drinkwater; Oola, Janet; Aloyo, Judith; Ikoona, Eric Nzirakaindi; Kitara, David Lagoro
Background: Coronavirus Disease 2019 (COVID-19) is a severe respiratory disease that results from infection with a new coronavirus (SARS-CoV-2). One of the most critical issues related to the COVID-19 is the high rate of spread, millions of people have been infected around the world, and hundreds of thousands of people have died till now. However, reports from Africa paint a different picture of the SARS-CoV-2 and its effects on the population. Objectives: The objective of this study was to describe the characteristics of the COVID-19 patients treated at the Gulu Regional Referral Hospital and determine factors associated with COVID-19 manifestations, socio-demographic characteristics, and treatment outcomes from March 2020 to October 2021. Methods: A retrospective data abstraction of all COVID-19 hospital admissions registered in the Gulu Health Management Information System (HMIS) database and other tools were conducted. The period of study was from March 2020 to October 2021. Data that met the inclusion criteria were consecutively abstracted from the Gulu Hospital HMIS database. A local IRB approved the study. SPSS version 25.0 was used for data analysis, and a p-value of 0.05 was considered significant. Results: Data suggests there were three waves of COVID-19 in Uganda. Those with comorbidities, e.g., Diabetes mellitus 38(5.7%), hypertension 83(12.5%), cardiovascular diseases 58(8.7%), HIV and AIDS 61(9.2%), and other comorbidities such as liver cirrhosis and Hepatitis B 40(6.0%) were more susceptible and presented with more severe forms of the disease. Antibiotics 662(99.7%), steroids 73(11.0%), vitamin C 564(84.9%), Ivermectin 7(1.1%), and Vitamin D 24(3.6%) were the most used medicines for the treatment of COVID-19 patients. Most COVID-19 patients were unvaccinated 661(99.5%). However, the recovery rate was 632(95.2%). The commonest complications were pneumonia 60(9.0%), chronic fatigue 49(7.4%), acute respiratory distress syndrome (ARDS) 37(5.6%), depression 20(3.0%), systemic infections 19(2.9%), nightmares 15(2.3%) and septic shock 8(1.2%). The Adjusted Odds Ratios (AOR) on factors associated with recovery were treatment with steroids AOR=138.835 at 95% CI:12.258-1572.50;p<0.000 and Vitamin D AOR=31.4780 at 95% CI:1.902520.98; p=0.016. Conclusion: This study showed successful management of COVID-19 patients in low-resource settings with a recovery rate of 95.2%. The admission pattern suggests Uganda had three waves of COVID-19, contrary to the official government position of two. Treatment with steroids and Vitamin D is associated with the recovery among COVID-19 patients. There is a need to conduct more extensive studies on the role played by the two drugs in the successful recovery of COVID-19 patients.
Correlates and prevalence of overweight and obesity among women of reproductive age (15-49 years) in Sierra Leone. A secondary data analysis of the demographic health survey of 2019
(2023-07-12) Okot Atim, Pamela; Alema, Nelson Onira; Pebolo, Francis Pebalo; Okot, Christopher; Ochula, Denis; Okot, Smart Geoffrey; Ikoona, Eric Nzirakaindi; Toure, Mame Awa; Namulemo, Lucy; Kamara, Kassim; Oyat, Freddy Wathum Drinkwater; Aloyo, Judith; Njenga, Amon; Kaluya, Ronald; Matovu, John Bosco; Olal, Emmanuel; Kitara, David Lagoro
Background: Overweight and obesity are emerging public health problems globally and are independent risk factors for heart, blood vessels, reproductive health, and metabolic disorders. This study aimed to determine the correlates and prevalence of overweight and obesity among women of reproductive age (15-49 years) in Sierra Leone using secondary data analysis of the Demographic Health Survey of 2019. Methods: This study was based on the 2019 Sierra Leone Demographic Health Survey (SLDHS) that used a two-stage stratified cluster sampling technique. A total of 7514 non-pregnant women of reproductive age (15-49 years) were used in the analysis. Simple descriptive, bivariable, and multivariable regression analyses were conducted with a significant p-value set at <0.05. Results: The prevalence of overweight and obesity among women of reproductive age in Sierra Leone was 19.7% and 7.4%, respectively. Overweight was more likely among women of 15-19 age group (adjusted Odds Ratios, aOR=1.933,95%CI:1.532- 2.348;p<0.001); women from the north (aOR=1.308,95%CI:1.104-1.581;p<0.006); women without formal education (aOR=1.211,95%CI:1.009-1.454;p<0.040); in poorest (aOR=1.501,95%CI:1.231-1.853;p<0.001) and poorer (aOR=1.419,95%CI:1.154-1.745;p=0.001) wealth indices. However, overweight was 39.9% less likely among 30-39-year (aOR=0.601,95%CI:0.507-0.713;p<0.001) and 49% less likely among 40-49-year (aOR=0.510,95%CI:0.415-0.628;p<0.001) age-groups. It was 27.3% less likely among married women (aOR=0.727,95%CI:0.613-0.863;p<0.001), 24.9% less likely in the south (aOR=0.751,95%CI:0.623-0.911;p=0.002), 38.2% and 48.7% less likely in richer (aOR=0.618,95%CI:0.494-0.773;p<0.001) and richest (aOR=0.513,95%CI:0.389-0.677;p<0.001) wealth indices, respectively. Also, obesity was more likely among women 15-19-year (aOR=2.051,95%CI:1.316-3.198;p=0.002); from the north (aOR=1.426,95%CI:1.038-1.958;p=0.044); in poorest (aOR=2.390,95%CI:1.618-3.532;p<0.001) and poorer (aOR=1.667,95%CI:1.151- 2.415;p=0.007) wealth indices. However, it was 68.3% and 79.6% less likely among women 30-39-year (aOR=0.317,95%CI:0.241-0.419;p<0.001) and 40-49-year (aOR=0.204,95%CI:0.149-0.278;p<0.001) age-groups, respectively. It was 36.8% less likely among female-headed households (aOR=0.732,95%CI:0.590-0.909;p=0.005) and 24% less likely among married women (aOR=0.760,95%CI:0.580-0.995;p=0.046); 26.2% less likely in the south (aOR=0.738,95%CI:0.550-0.992;p=0.044); 62.1% and 75.9% less likely in richer (aOR=0.379,95%CI:0.266-0.540;p<0.001) and richest (aOR=0.241,95%CI:0.159-0.367;p<0.001) wealth indices, respectively; and 39.9% less likely among women who listened to radios (aOR=0.601,95%CI:0.507-0.713;p<0.001). Conclusion: The prevalence of overweight and obesity among women of reproductive age (15-49 years) in Sierra Leone was higher compared to world data. Younger age groups, northern region, poorest and poorer wealth indices, and women without formal education were more likely to be overweight and obese. However, overweight and obesity were less likely among older age-groups, married, southern region, richer and richest wealth indices, female-headed households, and listening to radios. There is an urgent need for policymakers in Sierra Leone to tackle overweight and obesity among women of reproductive age (15-49 years) if the current trends are to be reversed.
Facemask wearing in COVID-19 pandemic:
(medRxiv, 2023-10-24) Alema, Nelson Onira; Okot, Christopher; Olal, Emmanuel; Ikoona, Eric Nzirakaindi; Oyat, Freddy Wathum Drinkwater; Baguma, Steven; Ochula, Denish Omoya; Olwedo, Patrick Odong; Oloya, Johnson Nyeko; Pebolo, Francis Pebalo; Atim, Pamela Okot; Okot, Godfrey Smart; Nantale, Ritah; Aloyo, Judith; Kitara, David Lagoro
Background: The WHO and the US. CDC documented that facemask-wearing in public situations is one of the most important prevention measures that can limit the acquisition and spread of COVID-19. Considering this, WHO and US. CDC developed guidelines for using facemasks in public settings. This study aimed to determine correlates and prevalence of facemask wearing during COVID-19 pandemic among adult population of Northern Uganda. Methods. We conducted a cross-sectional study on five hundred and eighty-seven adult population of northern Uganda. A single stage stratified, and systematic sampling methods were used to select respondents from twenty four Acholi subregion’s health facilities. Data was collected in a face-to-face questionnaire interview with an internal validity of Cronbach's α=0.72. A local IRB approved the study, and Stata 18 was used for data analysis at multivariable Poisson regression with a p-value set at ≤0.05. Results: The most substantial findings from this study were the high prevalence of face mask-wearing in public among respondents [88.7%,95%CI:86%-91%]. At a multivariable Poisson regression analysis, we found that obese respondents were 1.12 times more likely to wear facemasks than those who were not, [adjusted Interval Rates Ratios, aIRR=1.12,95%CI:1.04-1.19;p<0.01], and respondent who agreed to the lockdown measures were 1.23 times more likely to wear facemasks during COVID-19 pandemic than those who did not, [aIRR=1.23, 95%CI:1.07- 1.41;p<0.01]. Other sociodemographic characteristics such as sex, age, occupation, level of education, religion, tribes, marital status, nationality, race, and comorbidities were not statistically significant at 95% Confidence Intervals. Conclusion: The most significant findings from this study were the high prevalence of face mask-wearing among adult community members in northern Uganda. The correlates of facemask wearing in public were the obese and respondents who agreed with the presidential directives on the lockdown measures. Although this was within acceptable prevalence rates, the strict enforcement of face mask-wearing by security forces raised concerns among many community members and human rights advocates. We recommend more studies on communities' perspectives on the challenges and benefits of facemask-wearing during the COVID-19 pandemic.
Perceptions of COVID-19 vaccination among different adult age group populations in Northern Uganda. A cross-sectional study.
(Research squares, 2022-07-14) Oloya, Johnson Nyeko; Baguma, Steven; Okot, Christopher; Alema, Nelson Onira; Acullu, Denis; Ochula, Denis; Atim, Pamela; Olwedo, Patrick Odong; Okot, Smart Godfrey; Pebolo, Francis Pebalo; Freddy Wathum Drinkwater Oyat, Freddy Wathum Drinkwater; Ikoona, Eric Nzirakaindi; Aloyo, Judith; Oballim, Lawence; Kitara, David Lagoro
Introduction: Although COVID-19 first spread slowly in the African continent, confirmed virus cases have risen steadily since March 2020. The rapid spread of SARS-CoV-2 can be attributed to its numerous characteristics, including its high transmissibility, asymptomatic persons’ ability to shed the virus, vast numbers of asymptomatic persons, or mild symptoms but with the ability to transmit the virus, new variants, and super-spreading events. Poor public health practices,disbeliefs, myths, and misconceptions about the virus and its origin in many African communities are the other reasons for its rapid spread. This study aimed to determine the perceptions of the adult population in northern Uganda on the COVID-19 vaccine acceptance, disaggregated by age groups. Methods: A cross-sectional study was conducted between March and April 2022 to assess COVID-19 vaccine acceptance among seven hundred and twentythree adult populations selected randomly from the nine districts of the Acholi sub-region. A five-point Likert scale with responses categorized as Strongly Agree, "SA," Agree, "A," Neutral, "N," Disagree, "DA," and Strongly Disagree, "SD" was used to assess participants' acceptance of the COVID-19 vaccines. Ethical approval was obtained from a local IRB, and SPSS version 20.0 was used to perform multivariable logistic regression to identify factors associated with vaccine acceptance. A p-value less than 0.05 was considered significant. Results: The most significant finding was that COVID-19 vaccine acceptance among the adult population in northern Uganda disaggregated by age groups was not statistically significant (χ2=3.956; p=0.142). COVID-19 vaccine acceptance among the age groups was associated with trust in the information from the mainstream media χ2=20.105; p=0.000; Government of Uganda χ2=19.900; p=0.028 and social media 10.745; p=0.030. The independent predictors on perceptions of the COVID-19 vaccine acceptance among age groups were; Participants strongly agreed on its importance to protect them from the virus AoR=4.99;95% CI:1.626-15.337;p=0.005; Agreed that the vaccine would protect them from the virus AoR=3.44;95%CI:1.225-9.650;p=0.019; strongly agreed that the side effects of the vaccine would stop them from receiving the vaccine AoR=0.330; 95%CI:0.125-0.856; p=0.023; They were neutral on whether the side effects of the COVID-19 vaccine would stop them from getting a COVID-19 jab AoR= 0.320; 95%CI:0.108-0.952;p=0.027; would not accept to pay for the COVID-19 vaccine AoR=0.280;95%CI:0.093-0.866; p=0.027; Agreed that children could take a COVID-19 vaccine AoR= 0.260; 95%CI:0.105-0.626;p=0.003; Strongly agreed that children could return to school before the COVID-19 vaccination AoR= 2.330; 95%CI:1.103-4.916;p=0.027; and agreed that children could return to school before taking COVID-19 vaccines AoR= 3.320; 95%CI:1.225-9.014;p=0.018. Conclusion: COVID-19 vaccine acceptance among the study population disaggregated by age group was not significant despite the disinformation and misinformation in the Ugandan media. The independent determinants of COVID-19 vaccine acceptance were the importance of the vaccine in protecting against the virus, that the vaccine’s side effects could stop them from taking the vaccine, and that children could take the COVID-19 jab but could return to school before taking the COVID-19 jab. The fear of family members contracting the virus and self-isolation when infected contributed significantly to the COVID-19 vaccine acceptance among participants in northern Uganda. There is a need for health managers to engage, sensitize and mobilize the population by addressing concerns about long-term and immediate side effects to increase the COVID-19 vaccine uptake in this community.
Perceptions of COVID-19 vaccine among different adult age group populations in Northern Uganda: a cross-sectional study
(Journal of Global Health Reports., 2022-07-28) Kitara, David L; Baguma, Steven; Okot, Christopher; Acullu, Denis; Ochula, Denis; Okot, Pamela A; Odong, Patrick O; Okot, Smart G; Pebolo, Francis P; Oyat, Freddy W Drinkwater; Ikoona, Eric N; Alema, Nelson O; Oloya, Johnson N; Aloyo, Judith; Oballim, Lawence
Background: At the time when COVID-19 was declared a pandemic in March 2020, its spread in the African continent was slow. However, confirmed cases of the virus have since risen steadily over the years in the African continent for many reasons. This study aimed to determine factors associated with perceptions of COVID-19 vaccines among adult age-group populations in northern Uganda. Methods: We conducted this study as part of a larger study to determine factors associated with COVID-19 vaccine hesitancy/acceptance among 723 adult age-group populations selected by stratified and systematic sampling approaches from northern Uganda. We used a questionnaire with an internal validity of Cronbach’s α= 0.772. A five-point Likert scale, with responses categorized as strongly agree “SA”, agree “A”, neutral “N”, disagree “DA”, and strongly disagree “SD”, was used to assess participants’ perceptions on COVID-19 vaccines. A multivariable regression analysis was conducted with P-value set at <0.05. Results: Overall, 723 participated in the study with a mean age of 31.4 years (standard deviation,SD, +10.1). The majority 54.5% (n=394) were males. There were no significant differences in perceptions of COVID-19 vaccines among age-group populations (adjusted odds ratio, aOR=0.99, 95% confidence interval, CI=0.98-1.01). Key finding include: (i) it was important to take a COVID-19 vaccine (aOR=1.02, 95% CI=1.00-1.04); (ii) vaccines have unlikely unforeseen side effects (aOR=0.98, 95% CI=0.97-0.99); (iii) vaccines were unlikely being promoted for commercial gains (aOR=0.98, 95% CI=0.97-0.99); and children could take COVID-19 vaccines (aOR=1.02, 95% CI=1.00-1.03). Stratified by age-groups, the 20–29-year-old perceived COVID-19 vaccines developed in Uganda as unlikely safe and effective (aOR=0.59, 95% CI=0.35-0.97), and COVID-19 vaccines have likely unforeseen side-effects (aOR=2.1, 95% CI=1.3-3.6). While the ≥50-year-old group perceived that COVID-19 vaccines were unlikely being promoted for commercial gains (aOR=0.2, 95% CI=0.1-0.6). Conclusions: There were no substantial differences in perceptions on COVID-19 vaccines in adult age-group populations in northern Uganda. The determinants of COVID-19 vaccine perceptions were its importance against the virus; vaccines have unlikely unforeseen side-effects, and children could take it. Stratified by age-groups, some age-groups perceived COVID-19 vaccines developed in Uganda as unlikely safe and unlikely being promoted for commercial gains
Trusted sources of information on COVID-19 vaccines during the pandemic in Uganda:
(Research squares, 2023-10-17) Oloya, Johnson Nyeko; Alema, Nelson Onira; Okot, Christopher; Olal, Emmanuel; Ikoona, Eric Nzirakaindi; Oyat, Freddy Wathum Drinkwater; Steven, Baguma; Ochula, Denish Omoya; Olwedo, Patrick Odong; Pebolo, Francis Pebalo; Atim, Pamela Okot; Okot, Godfrey Smart; Nantale, Ritah; Aloyo, Judith; Kitara, David Lagoro
Background. COVID-19 has dramatically impacted communities worldwide, especially in developing countries. To successfully control the COVID-19 pandemic, more than 80% vaccination coverage was required, and the flow of correct information to the population was critical. However, misinformation and disinformation could impact this, increasing COVID-19 vaccine hesitancy in some communities. Several studies have assessed the effect of misinformation and disinformation on COVID-19 vaccine acceptance and other responses to the pandemic in the African continent. Thus, the most trusted sources of information on COVID-19 vaccines to the population is critical for successfully managing and controlling the pandemic. This study aimed to assess the most trusted sources of information on COVID-19 vaccines during the pandemic in northern Uganda. Methods. We conducted a cross-sectional study on 587 adult population members in northern Uganda. Stratified and systematic sampling methods were used for selecting participants from twenty-four health facilities in the Acholi subregion. Data were collected using an interviewer-administered questionnaire with an internal validity of Cronbach's α=0.72. A local IRB approved the study, and Stata version 18 was used for data analysis. A Pearson Chi-square (χ2) analysis was conducted to assess the association between trusted sources of information on COVID-19 vaccines among study participants and selected independent variables. Fisher's exact test assessed association when cell value following crosstabulation was ≤5. A P-value <0.05 was used as evidence for an association between the trusted sources of information and independent variables. All results were presented as frequencies and proportions and Chi-square or Fisher's exact test P-values at 95% Confidence Intervals (CI). Results: In a study of 587, most participants were males, 335(57.1%), in the age group of 25-34 years, 180(31.4%), and the most trusted source of information on COVID-19 vaccines were the traditional media sources such as Televisions, Radios, and Newspapers, 349(33.6%). There was no significant association between sex and sources of information on COVID-19 vaccines. However, by age group population, it was significantly associated with internet use (14.7% versus 85.3%; p=0.02), information from family members (9.4% versus 90.6%; p<0.01), and the Government/Ministry of Health (37.9% versus 62.1%; p<0.01). In addition, it was significantly associated with internet use (32.2% versus 67.8%; p=0.03), healthcare providers (32.5% versus 67.5%; p<0.018), the Government/Ministry of Health (31.1% versus 68.9%; p<0.01), and scientific articles (44.7% versus 55.3%; p<0.01) in healthcare workers compared to non-health workers. Conclusion. The most substantial finding from our study was that the most trusted sources of information on COVID-19 vaccines in northern Uganda were Television, Radio, and Newspapers. There were no significant differences in the most trusted sources of information on COVID-19 vaccines between the sexes but significant differences by age groups and occupations, with the younger age groups and non-healthcare workers having more trust in TVs, Radios, and Newspapers. For effective management of an epidemic, there is a need for accurate communication so that misinformation, disinformation, and malinformation do not disrupt the flow of information to communities.

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