Absolute eosinophil count correlates with temperature and CD4 count independently of HIV infection among tuberculosis patients
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Date
2020-09
Journal Title
Journal ISSN
Volume Title
Publisher
Tropical Medicine and International Health
Abstract
objective To determine clinical correlates of the peripheral absolute eosinophil count (AEC) among
bacteriologically confirmed TB patients in Uganda.
materials and methods We evaluated data of bacteriologically confirmed adult TB patients who
had a peripheral blood AEC measurement at the National TB Treatment Center in Uganda during a
cross-sectional study. We performed linear regression analysis for correlates of log-transformed AEC.
results We included 235 patients in this analysis with a median (interquartile range, IQR) age of
31 (24–39) years. 60.4% were male, and 33.6% had TB/HIV co-infection. In a multivariable linear
regression model that controlled for age, residence type, HIV status, weight loss, anorexia, body mass
index, CD8+ T-cell count, haemoglobin level and TB bacillary load, males had a 47.0% higher AEC
than females (adjusted coefficient (R2
) = 0.385, 95% confidence interval (CI) 0.012–0.759
P = 0.043). Also, a 1 °C raise in temperature resulted in an 11.5% decrease in the AEC
(R2 = 0.122 95% CI ( 0.233 to 0.011) P = 0.031) while a 1 cell/mm3 increase in the CD4+ T cell count resulted in a 0.10% increase in the AEC (R2 = 0.001 95% CI (0.000–0.001) P = 0.032).
conclusion The AEC was higher among males than females, consistent with the normal population
distribution of AEC among Ugandans. The AEC was weakly but positively correlated with the CD4
count and negatively correlated with temperature.
Description
Keywords
eosinophil count,, CD4,, tuberculosis,, HIV,, Uganda,, symptoms,, temperature,, eosinophilia
Citation
Baluku, J. B., Anguzu, G. T., Bongomin, F., & Byonanebye, D. M. (2020). Absolute eosinophil count correlates with temperature and CD4 count independently of HIV infection among tuberculosis patients. Tropical Medicine & International Health, 25(9), 1079-1084.