High Mortality During the Second Wave of the Coronavirus Disease 2019 (COVID-19) Pandemic in Uganda: Experience From a National Referral COVID-19 Treatment Unit
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Date
2021-10-18
Journal Title
Journal ISSN
Volume Title
Publisher
Oxford University Press
Abstract
Background. We evaluated clinical outcomes of patients hospitalized with coronavirus disease 2019 (COVID-19) in the second
wave of the pandemic in a national COVID-19 treatment unit (CTU) in Uganda.
Methods. We conducted a retrospective cohort study of COVID-19 patients hospitalized at the Mulago National Referral
Hospital CTU between May 1 and July 11, 2021. We performed Kaplan-Meier analysis to evaluate all-cause in-hospital mortality.
Results. Of the 477 participants, 247 (52%) were female, 15 (3%) had received at least 1 dose of the COVID-19 vaccine, and 223
(46%) had at least 1 comorbidity. The median age was 52 (interquartile range, 41–65) years. More than 80% of the patients presented
with severe (19%, n = 91) or critical (66%, n = 315) COVID-19 illness. Overall, 174 (37%) patients died. Predictors of all-cause
in-hospital mortality were as follows; age ≥50 years (adjusted odds ratio [aOR], 1.9; 95% confidence interval [CI], 1.2–3.2; P = .011),
oxygen saturation at admission of ≥92% (aOR, 0.97; 95% CI, 0.91–0.95; P < .001), and admission pulse rate of ≥100 beats per minute
(aOR, 1.01; 95% CI, 1.00–1.02; P = .042). The risk of death was 1.4-fold higher in female participants compared with their male coun terparts (hazards ratio, 1.4; 95% CI, 1.0–2.0; P = .025).
Conclusions. In this cohort, where the majority of the patients presented with severe or critical illness, more than one third of
the patients hospitalized with COVID-19 at a national CTU died of the illness.
Description
Keywords
COVID-19;, mortality;, high-dependency unit;, second wave;, Uganda.
Citation
Bongomin, F., Fleischer, B., Olum, R., Natukunda, B., Kiguli, S., Byakika-Kibwika, P., ... & Nakwagala, F. N. (2021, November). High mortality during the second wave of the coronavirus disease 2019 (COVID-19) pandemic in Uganda: experience from a national referral COVID-19 treatment unit. In Open Forum Infectious Diseases (Vol. 8, No. 11, p. ofab530). US: Oxford University Press.