Predictors of laboratory spontaneous tumour lysis syndrome in children with high-grade tumours in Uganda

dc.contributor.authorApiyo, Mirriam
dc.contributor.authorBongomin, Felix
dc.contributor.authorBalagadde, Joyce
dc.contributor.authorMupere, Ezekiel
dc.contributor.authorNdeezi, Grace
dc.date.accessioned2023-11-23T15:32:15Z
dc.date.available2023-11-23T15:32:15Z
dc.date.issued2021
dc.description.abstractHigh-grade malignancy is endemic in sub-Saharan Africa and is prone to the spontaneous tumour lysis syndrome. However, data on spontaneous tumour lysis syndrome remain scanty in our setting. We sought to determine the prevalence and factors associated with laboratory spontaneous tumour lysis syndrome in children in Uganda. We conducted a cross-sectional study among children <18 years old with histologically confirmed high-grade malignancy between October 2013 and April 2014. Laboratory spontaneous tumour lysis syndrome was defined as the presence of 2 of each of hyperkalaemia, hypocalcaemia, hyperuricaemia and hyperphosphatemia prior to administration of chemo therapy when alternative diagnoses had been excluded. A p < 0.05 was considered statistically significant. Of 108 chil dren, of median age 7.7 years, where boys outnumbered girls 2:1, high-grade, malignancy included Burkitt’s lymphoma, acute lymphoblastic leukaemia, non-Hodgkin’s lymphoma, acute myeloid leukaemia and Burkitt’s leukaemia, with 14 suffering with laboratory spontaneous tumour lysis syndrome. Hypocalcaemia was its most common electrolyte imbal ance; and four children died prior to commencement of chemotherapy. Bulky disease, lactate dehydrogenase levels 500 iu/l and serum creatinine levels >1.2 mg/dl were associated with laboratory spontaneous tumour lysis syndrome. However, only bulky disease was significantly predictive of laboratory spontaneous tumour lysis syndrome. Such children would benefit from routine screeningen_US
dc.identifier.citationApiyo, M., Bongomin, F., Balagadde, J., Mupere, E., & Ndeezi, G. (2021). Predictors of laboratory spontaneous tumour lysis syndrome in children with high-grade tumours in Uganda. Tropical Doctor, 51(4), 501-507.en_US
dc.identifier.otherhttps://doi.org/10.1177/00494755211029782
dc.identifier.urihttps://hdl.handle.net/20.500.14270/340
dc.language.isoenen_US
dc.publisherSageen_US
dc.subjectTumour lysis syndrome,en_US
dc.subjectBurkitt’s lymphoma,en_US
dc.subjectacute leukaemia,en_US
dc.subjectUgandaen_US
dc.titlePredictors of laboratory spontaneous tumour lysis syndrome in children with high-grade tumours in Ugandaen_US
dc.typeArticleen_US

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