HIV and fungal priority pathogens
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Date
2023-11-01
Authors
Alastruey-Izquierdo, Ana
FRCPath, Nelesh P. Govender
John, Perfect
Hatim, Sati
Harrison, Tom
Chiller, Tom
Sorrell, Tania
Bongomin, Felix
Oladele, Rita
Chakrabarti, Arunaloke
Journal Title
Journal ISSN
Volume Title
Publisher
Europe PMC Funders Group
Abstract
The burden of invasive fungal infections associated with opportunistic fungal pathogens is a persistent challenge, particularly among people with advanced HIV disease. In October,2022, WHO published the Fungal Priority Pathogens List (FPPL)—the first global effort to systematically prioritise fungal pathogens. Of the 19 pathogens in the WHO FPPL, four opportunistic pathogens in particular cause invasive diseases in people living with HIV: Cryptococcus neoformans, Histoplasma spp, Pneumocystis jirovecii, and Talaromyces marneffei. These four fungal pathogens are major causes of illness and death in people with advanced
HIV and overwhelmingly affect those in low-income and middle-income countries. Access to diagnostics, improved surveillance, targeted support for innovation, and an enhanced public health focus on these diseases are needed in the effort to reduce HIV-associated deaths.
Description
Keywords
HIV, fungal, opportunistic fungal pathogens
Citation
Sati, H., Alastruey-Izquierdo, A., Perfect, J., Govender, N. P., Harrison, T. S., Chiller, T., ... & Ford, N. (2023). HIV and fungal priority pathogens. The Lancet HIV, 10(11), e750-e754.