Burden and associated phenotypic characteristics of tuberculosis infection in adult Africans with diabetes: a systematic review

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dc.contributor.authorKibirige, Davis
dc.contributor.authorBiraro, IreneAndia
dc.contributor.authorKyazze, Andrew Peter
dc.contributor.authorOlum, Ronald
dc.contributor.authorBongomin, Felix
dc.contributor.authorNakavuma, Rose Mwanje
dc.contributor.authorSsekamatte, Phillip
dc.contributor.authorEmoru, Reagan
dc.contributor.authorNalubega, Goretti
dc.contributor.authorChamba, Nyasatu
dc.contributor.authorKilonzo, Kajiru
dc.contributor.authorLaizer, Sweetness Naftal
dc.contributor.authorMrema, Lucy Elauteri
dc.contributor.authorOlomi, Willyhelmina
dc.contributor.authorMinja, LilianTina
dc.contributor.authorNtinginya, Nyanda Elias
dc.contributor.authorSabi, Issa
dc.contributor.authorHill, Philip C.
dc.contributor.authorBrake, Lindsey te
dc.contributor.authorCrevel, Reinout van
dc.contributor.authorSharples, Katrina
dc.contributor.authorCritchley, Julia
dc.date.accessioned2024-02-05T12:33:02Z
dc.date.available2024-02-05T12:33:02Z
dc.date.issued2023
dc.description.abstractDiabetes mellitus (DM) increases the risk of developing tuberculosis infection (TBI). However, the evidence on the burden and phenotypic characteristics of TBI in African patients with DM is limited. This study aimed to determine the prevalence and characterisation of TBI in native African patients living with DM. We searched PubMed, EMBASE, and African Journals Online for original studies reporting information on the prevalence and characteristics of TBI in adult Africans with DM. A forest plot was used to describe the pooled prevalence estimate of TBI and the corresponding 95% confdence intervals (CI). Six studies conducted in four African countries involving 721 participants with DM were included in this systematic review. The pooled prevalence estimate of TBI was 40% (95% CI 20–60%, I 2 = 98.52%, p< 0.001). Age ≥ 40 years and glycated haemoglobin levels independently predicted TBI positivity in patients with DM in three studies. Africans with DM have a high prevalence of TBI, especially those who are older or with poorly controlled diabetes. This justifes the need for studies to explore how to screen and manage TBI to avert the progression to active TB diseaseen_US
dc.description.sponsorshipFunded by the European and Developing Countries Clinical Trials Partnership (EDCTP) 2 program supported by the European Union (grant number RIA2018CO-2514-PROTID)en_US
dc.identifier.citationKibirige, D., Andia-Biraro, I., Kyazze, A. P., Olum, R., Bongomin, F., Nakavuma, R. M., ... & Critchley, J. (2023). Burden and associated phenotypic characteristics of tuberculosis infection in adult Africans with diabetes: a systematic review. Scientific Reports, 13(1), 19894.en_US
dc.identifier.urit https://doi.org/ 10.1038/s41598-023-47285-4
dc.identifier.urihttps://hdl.handle.net/20.500.14270/455
dc.publisherSpringer Natureen_US
dc.relation.ispartofseriesScientifc Reports;(2023) 13:19894
dc.subjectDiabetes mellitusen_US
dc.subjectphenotypic characteristics of TBIen_US
dc.subjecttuberculosis infectionen_US
dc.titleBurden and associated phenotypic characteristics of tuberculosis infection in adult Africans with diabetes: a systematic reviewen_US
dc.typeArticleen_US

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