Innate and Adaptive Immune Defects in Chronic Pulmonary Aspergillosis
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Date
2017-05-29
Journal Title
Journal ISSN
Volume Title
Publisher
Journal of Fungi
Abstract
We evaluated the expression of biomarkers of innate and adaptive immune response in
correlation with underlying conditions in 144 patients with chronic pulmonary aspergillosis
(CPA). Patients with complete medical and radiological records, white cell counts, and a complete
panel of CD3, CD4, CD8, CD19, and CD56 lymphocyte subsets were included. Eighty-four (58%)
patients had lymphopenia. Six (4%) patients had lymphopenia in all five CD variables. There were
62 (43%) patients with low CD56 and 62 (43%) patients with low CD19. Ten (7%) patients had
isolated CD19 lymphopenia, 18 (13%) had isolated CD56 lymphopenia, and 15 (10%) had
combined CD19 and CD56 lymphopenia only. Forty-eight (33%) patients had low CD3 and 46
(32%) had low CD8 counts. Twenty-five (17%) patients had low CD4, 15 (10%) of whom had
absolute CD4 counts <200/μL. Multivariable logistic regression showed associations between: low
CD19 and pulmonary sarcoidosis (Odds Ratio (OR), 5.53; 95% Confidence Interval (CI), 1.43–21.33;
p = 0.013), and emphysema (OR, 4.58; 95% CI; 1.36–15.38; p = 0.014), low CD56 and no
bronchiectasis (OR, 0.27; 95% CI, 0.10–0.77; p = 0.014), low CD3 and both multicavitary CPA
disease (OR, 2.95; 95% CI, 1.30–6.72; p = 0.010) and pulmonary sarcoidosis (OR, 4.94; 95% CI,
1.39–17.57; p = 0.014). Several subtle immune defects are found in CPA.
Description
Keywords
chronic pulmonary aspergillosis;, innate and adaptive immune defects;, underlying lung disease
Citation
Bongomin, F., Harris, C., Foden, P., Kosmidis, C., & Denning, D. W. (2017). Innate and adaptive immune defects in chronic pulmonary aspergillosis. Journal of Fungi, 3(2), 26.