Burden and associated phenotypic characteristics of tuberculosis infection in adult Africans with diabetes: a systematic review

Simple item page
dc.contributor.authorKibirige, Davis
dc.contributor.authorAndia‑Biraro, Irene
dc.contributor.authorKyazze, Andrew Peter
dc.contributor.authorOlum, Ronald
dc.contributor.authorBongomin, Felix
dc.contributor.authorMwanje Nakavuma, Rose
dc.contributor.authorSsekamatte, Phillip
dc.contributor.authorEmoru, Reagan
dc.contributor.authorNalubega, Goretti
dc.contributor.authorChamba, Nyasatu
dc.contributor.authorKilonzo, Kajiru
dc.contributor.authorNaftal Laizer, Sweetness
dc.contributor.authorElauteri Mrema, Lucy
dc.contributor.authorOlomi, Willyhelmina
dc.contributor.authorMinja, Lilian Tina
dc.contributor.authorNtinginya, Nyanda Elias
dc.contributor.authorSabi, Issa
dc.contributor.authorHill, Philip C.
dc.contributor.authorte Brake, Lindsey
dc.contributor.authorvan Crevel, Reinout
dc.contributor.authorSharples, Katrina
dc.contributor.authorCritchley, Julia
dc.date.accessioned2023-11-20T11:01:41Z
dc.date.available2023-11-20T11:01:41Z
dc.date.issued2023-11-11
dc.description.abstractDiabetes mellitus (DM) increases the risk of developing tuberculosis infection (TBI). However, the evidence on the burden and phenotypic characteristics of TBI in African patients with DM is limited. This study aimed to determine the prevalence and characterisation of TBI in native African patients living with DM. We searched PubMed, EMBASE, and African Journals Online for original studies reporting information on the prevalence and characteristics of TBI in adult Africans with DM. A forest plot was used to describe the pooled prevalence estimate of TBI and the corresponding 95% confdence intervals (CI). Six studies conducted in four African countries involving 721 participants with DM were included in this systematic review. The pooled prevalence estimate of TBI was 40% (95% CI 20–60%, I 2 = 98.52%, p< 0.001). Age ≥ 40 years and glycated haemoglobin levels independently predicted TBI positivity in patients with DM in three studies. Africans with DM have a high prevalence of TBI, especially those who are older or with poorly controlled diabetes. This justifes the need for studies to explore how to screen and manage TBI to avert the progression to active TB disease.en_US
dc.description.sponsorshipEuropean and Developing Countries Clinical Trials Partnership (EDCTP) 2 program supported by the European Union (grant number RIA2018CO-2514-PROTID).en_US
dc.identifier.citationKibirige, D., Andia-Biraro, I., Kyazze, A. P., Olum, R., Bongomin, F., Nakavuma, R. M., ... & Critchley, J. (2023). Burden and associated phenotypic characteristics of tuberculosis infection in adult Africans with diabetes: a systematic review. Scientific Reports, 13(1), 19894.en_US
dc.identifier.urihttps://doi.org/10.1038/s41598-023-47285-4
dc.identifier.urihttps://hdl.handle.net/20.500.14270/330
dc.language.isoenen_US
dc.publisherScientific Reportsen_US
dc.relation.ispartofseries;1
dc.titleBurden and associated phenotypic characteristics of tuberculosis infection in adult Africans with diabetes: a systematic reviewen_US
dc.typeArticleen_US

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Bongomin Felix_FOM_2023_1.pdf
Size:
1.56 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Research Articles