Prevalence of Intestinal Helminth Coinfection in Drug-Resistant Tuberculosis in Uganda

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dc.contributor.authorBaruch Baluku, Joseph
dc.contributor.authorNakazibwe, Bridget
dc.contributor.authorWasswa, Amir
dc.contributor.authorNaloka, Joshua
dc.contributor.authorNtambi, Samuel
dc.contributor.authorWaiswa, Damalie
dc.contributor.authorOkwir, Mark
dc.contributor.authorNabwana, Martin
dc.contributor.authorBongomin, Felix
dc.contributor.authorKaturamu, Richard
dc.contributor.authorNuwagira, Edwin
dc.contributor.authorNtabadde, Kauthrah
dc.contributor.authorKatongole, Paul
dc.contributor.authorSenyimba, Catherine
dc.contributor.authorAndia-Biraro, Irene
dc.date.accessioned2023-11-24T12:25:11Z
dc.date.available2023-11-24T12:25:11Z
dc.date.issued2022-10-08
dc.description.abstractBackground. Although a third of people with tuberculosis (TB) are estimated to be coinfected with helminths, the prevalence is largely unknown among people with drug-resistant TB (DR-TB). We determined the prevalence of helminth coinfection among people with DR-TB in Uganda. Methods. In a multicenter, cross-sectional study, eligible Ugandan adults with confirmed DR-TB were consecutively enrolled between July to December 2021 at 4 treatment centers. Sociodemographic data were collected using a questionnaire. Participants underwent anthropometric and blood pressure measurements, and blood samples were evaluated for random blood glucose, glycated hemoglobin, nonfasting lipid profile, human immunodeficiency virus (HIV) infection, and a complete blood count. Fresh stool samples were evaluated for adult worms, eggs, and larvae using direct microscopy after Kato-Katz concentration techniques. Results. Of 212 participants, 156 (73.6%) were male, 118 (55.7%) had HIV, and 3 (2.8%) had malaria coinfection. The prevalence of intestinal helminth coinfection was 4.7% (10/212) (95% confidence interval, 2.6%–8.6%). The frequency of helminth infections was Ancylostoma duodenale (n=4), Schistosoma mansoni (n=2), Enterobius vermicularis (n=2), Ascaris lumbricoides (n=1), and Trichuris trichiura (n=1). Conclusions. The prevalence of helminth coinfection was low among people with DR-TB. More studies are needed to determine the clinical relevance of helminth/DR-TB coinfection.en_US
dc.description.sponsorshipNational Institute for Health and Care Research through the Royal Society of Tropical Medicine and Hygiene.en_US
dc.identifier.citationBaluku, J. B., Nakazibwe, B., Wasswa, A., Naloka, J., Ntambi, S., Waiswa, D., ... & Andia-Biraro, I. (2022, October). Prevalence of Intestinal Helminth Coinfection in Drug-Resistant Tuberculosis in Uganda. In Open Forum Infectious Diseases (Vol. 9, No. 10, p. ofac541). US: Oxford University Press.en_US
dc.identifier.otherhttps://doi.org/10.1093/ofid/ofac541
dc.identifier.urihttps://academic.oup.com/ofid/article/9/10/ofac541/6756459
dc.identifier.urihttps://hdl.handle.net/20.500.14270/352
dc.language.isoenen_US
dc.publisherOxford University Pressen_US
dc.subjectDR-TB;en_US
dc.subjectdrug-resistant tuberculosis;en_US
dc.subjecthelminth;en_US
dc.subjectMDR;en_US
dc.subjectTB;en_US
dc.subjectwormsen_US
dc.titlePrevalence of Intestinal Helminth Coinfection in Drug-Resistant Tuberculosis in Ugandaen_US
dc.typeArticleen_US

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