Cardiovascular risk factors among people with drug-resistant tuberculosis in Uganda
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Date
2022-10-10
Journal Title
Journal ISSN
Volume Title
Publisher
BMC
Abstract
Background Tuberculosis (TB) and its risk factors are independently associated with cardiovascular disease (CVD). We
determined the prevalence and associations of CVD risk factors among people with drug-resistant tuberculosis (DRTB)
in Uganda.
Methods In this cross-sectional study, we enrolled people with microbiologically confirmed DRTB at four treatment
sites in Uganda between July to December 2021. The studied CVD risk factors were any history of cigarette smoking,
diabetes mellitus (DM) hypertension, high body mass index (BMI), central obesity and dyslipidaemia. We used
modified Poisson regression models with robust standard errors to determine factors independently associated with
each of dyslipidaemia, hypertension, and central obesity.
Results Among 212 participants, 118 (55.7%) had HIV. Overall, 196 (92.5%, 95% confidence interval (CI) 88.0-95.3)
had≥1 CVD risk factor. The prevalence; 95% CI of individual CVD risk factors was: dyslipidaemia (62.5%; 55.4–69.1),
hypertension (40.6%; 33.8–47.9), central obesity (39.3%; 32.9–46.1), smoking (36.3%; 30.1–43.1), high BMI (8.0%;
5.0–12.8) and DM (6.5%; 3.7–11.1). Dyslipidaemia was associated with an increase in glycated haemoglobin (adjusted
prevalence ratio (aPR) 1.14, 95%CI 1.06–1.22). Hypertension was associated with rural residence (aPR 1.89, 95% CI 1.14–
3.14) and previous history of smoking (aPR 0.46, 95% CI 0.21–0.98). Central obesity was associated with increasing age
(aPR 1.02, 95%CI 1.00–1.03), and elevated diastolic blood pressure (aPR 1.03 95%CI 1.00–1.06).
Conclusion There is a high prevalence of CVD risk factors among people with DRTB in Uganda, of which
dyslipidaemia is the commonest. We recommend integrated services for identification and management of CVD risk
factors in DRTB.
Description
Keywords
Smoking,, Diabetes,, Hypertension,, Lipids,, TB,, Cardiovascular,, Cholesterol,, Obesity,, MDR TB
Citation
Baluku, J. B., Nabwana, M., Nalunjogi, J., Muttamba, W., Mubangizi, I., Nakiyingi, L., ... & Worodria, W. (2022). Cardiovascular risk factors among people with drug-resistant tuberculosis in Uganda. BMC Cardiovascular Disorders, 22(1), 1-10.