Prevalence of Use of Herbal Medicines for the Treatment of Sickle Cell Disease in Africa: a Systematic Review and Meta-analysis
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Date
2023-08-11
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier
Abstract
Introduction: Several herbal medicines have been reported to ameliorate sickle cell disease (SCD) complications
in many African communities. However, no comprehensive review has evaluated the use of herbal remedies for
treating SCD crises. Therefore, this study aimed to determine the prevalence of the use of herbal medicines for
the treatment of SCD in Africa.
Methods: Following registration of the review protocol with PROSPERO (CRD42022346755), searched PubMed,
Embase, Africa Journal Online, and Web of Science databases using the keywords ‘herbal medicine,’ ‘SCD,’ and
‘Africa’ on 1st August 2022 for peer-reviewed articles without language restriction. We included articles that
reported the prevalence of herbal medicine use for SCD treatment in Africa and excluded qualitative studies,
letters to editors, case reports, and editorials. All included papers were assessed using the modified Newcastle Ottawa quality assessment scale for observational studies. We used the random-effect model to calculate the
pooled prevalence of herbal medicine use for SCD treatment with STATA 17.0.
Results: Overall, 142 research articles were identified. Of this, three cross-sectional studies involving 702 chil dren with SCD from Uganda (n = 1) and Nigeria (n = 2) met the eligibility criteria and were included. Four
hundred thirty-four individuals from the included studies used herbal medicines for the management of SCD.
The prevalence of current herbal medicine use in individual studies ranged from 36.4% to 78.0%, with a pooled
prevalence of 59% (95% confidence interval: 35.0–82.0, I
2 = 97.68%, P < 0.001).
Conclusions: Almost three in five persons with SCD in Africa use herbal remedies as a form of treatment.
However, there is limited data detailing the magnitude of the prevalence of use of herbal medicines for the
treatment of SCD across different regions. Therefore, further studies are encouraged to explore the prevalence of
use of herbal remedies for the management of SCD in Africa.
Description
Keywords
Herbal remedies use, Treatment, Sickle cell anaemia, Africa, Systematic review
Citation
Awor, S., Bongomin, F., Kaggwa, M. M., Pebalo, F. P., & Musoke, D. (2023). Prevalence of use of herbal medicines for the treatment of sickle cell disease in Africa: a systematic review and meta-analysis. Journal of Herbal Medicine, 100735.