Diagnostic Accuracy of Clinical Diagnostic Scoring Systems for Childhood Tuberculosis: A Systematic Review and Meta-analysis

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dc.contributor.authorKakinda, Michael
dc.contributor.authorOlum, Ronald
dc.contributor.authorBaluku, Joseph Baruch
dc.contributor.authorBongomin, Felix
dc.date.accessioned2024-02-02T10:43:27Z
dc.date.available2024-02-02T10:43:27Z
dc.date.issued2023-12-11
dc.description.abstractBackground. Diagnosis of childhood tuberculosis (TB) poses several challenges. Therefore, point-based scoring systems and diagnostic algorithms have been developed to improve the diagnostic yields in this population. However, there are no updated systematic reviews of the existing childhood TB scoring systems and algorithms. Hence, we systematically reviewed the diagnostic accuracy of the childhood TB diagnostic scoring systems and algorithms. Methods. We systematically searched PubMed, CINAHL, Embase, Scopus, and Google Scholar databases for relevant articles published until 30 March 2023. QUADAS-2 was used to assess their study quality. Diagnostic accuracy measures (ie, sensitivity, specificity, diagnostic odds ratio, positive and negative likelihood ratios) were pooled using a random-effects model. Results. We included 15 eligible studies, with a total of 7327 study participants aged <15 years, with 10 evaluations of childhood TB diagnostic scoring systems and algorithms. Among these algorithms and scoring systems, only 3 were evaluated more than once. These were the Keith Edwards scoring system with 5 studies (sensitivity, 81.9%; specificity, 81.2%), Kenneth Jones criteria with 3 studies (sensitivity, 80.1%; specificity, 45.7%), and the Ministry of Health–Brazil algorithm with 3 studies (sensitivity, 79.9%; specificity, 73.2%). Conclusions. We recommend using the Keith Edwards scoring system because of its high sensitivity and specificity. Further research is necessary to assess the effectiveness of scoring systems and algorithms in identifying TB in children with HIV and malnutrition.en_US
dc.description.sponsorshipSupported by the Fogarty International Center of the NIH (award number D43TW010543).en_US
dc.identifier.citationKakinda, M., Olum, R., Baluku, J. B., & Bongomin, F. (2024, January). Diagnostic Accuracy of Clinical Diagnostic Scoring Systems for Childhood Tuberculosi Systematic Review and Meta-analysis. In Open Forum Infectious Diseases (Vol. 11, No. 1, p. ofad624). US: Oxford University Press.en_US
dc.identifier.urihttps://doi.org/10.1093/ofid/ofad624
dc.identifier.urihttps://hdl.handle.net/20.500.14270/445
dc.language.isoenen_US
dc.publisherOxford University Pressen_US
dc.relation.ispartofseriesOFID;2024
dc.subjectdiagnostic scoring systemen_US
dc.subjectdiagnostic test accuracyen_US
dc.subjectpediatric TB.en_US
dc.titleDiagnostic Accuracy of Clinical Diagnostic Scoring Systems for Childhood Tuberculosis: A Systematic Review and Meta-analysisen_US
dc.typeArticleen_US

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