Treatment outcomes of pregnant women with drug-resistant tuberculosis in Uganda: A retrospective review of 18 cases
| dc.contributor.author | Baruch Baluku, Joseph | |
| dc.contributor.author | Bongomin, Felix | |
| dc.date.accessioned | 2023-11-25T07:47:02Z | |
| dc.date.available | 2023-11-25T07:47:02Z | |
| dc.date.issued | 2021-02-06 | |
| dc.description.abstract | Background: There is a dearth of reports on drug-resistant tuberculosis (DRTB) treatment outcomes among pregnant women in tuberculosis (TB)/HIV high-burdened countries. We report treatment outcomes of 18 pregnant women with DRTB in Uganda. Methods: We reviewed charts of individuals who received DRTB treatment in Uganda across 16 DRTB treatment sites. We included all women who were pregnant during DRTB treatment and had a treatment outcome documented between 2013 and 2019. Results: There were 18 pregnant women with a mean age (standard deviation (SD)) of 27.5 (5.2) years, of whom 8 (44.4%) were HIV co-infected. Among these women, 12 (66.7%) had primary DRTB and 8 (44.4%) had multidrug-resistant TB. Levofloxacin (Lfx), Pyrazinamide, Cycloserine and Kanamycin (Kn) were the most (>78%) used drugs in the treatment regimen and the mean (SD) treatment duration was 17.6 (7.5) months. Elevated liver enzymes (81.8%, n = 11) and hearing loss (33.3%, n = 15) were the most frequently encountered drug adverse events. Treatment success was observed among 15 (83.3%) patients, 2 (11.1%) patients were lost to follow up and 1 (5.6%) patient died. Conclusion: The treatment success among pregnant women with DRTB in Uganda was high despite a high prevalence of HIV co-infection. | en_US |
| dc.description.sponsorship | East African Public Health Laboratory Networking (EAPHLN) Project, Uganda under the Ministry of Health, which was supported by the World Bank. | en_US |
| dc.identifier.citation | Baluku, J. B., & Bongomin, F. (2021). Treatment outcomes of pregnant women with drug-resistant tuberculosis in Uganda: a retrospective review of 18 cases. International Journal of Infectious Diseases, 105, 230-233. | en_US |
| dc.identifier.other | https://doi.org/10.1016/j.ijid.2021.02.032 | |
| dc.identifier.uri | http://www.elsevier.com/locate/ijid | |
| dc.identifier.uri | https://hdl.handle.net/20.500.14270/359 | |
| dc.language.iso | en | en_US |
| dc.publisher | Elsevier | en_US |
| dc.subject | Drug-resistant tuberculosis | en_US |
| dc.subject | MDR TB | en_US |
| dc.subject | Pregnancy | en_US |
| dc.subject | Uganda | en_US |
| dc.subject | HIV | en_US |
| dc.subject | Women | en_US |
| dc.title | Treatment outcomes of pregnant women with drug-resistant tuberculosis in Uganda: A retrospective review of 18 cases | en_US |
| dc.type | Article | en_US |