Browsing by Author "Apiyo, Mirriam"

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    Clinical Characteristics and Outcomes of Patients Hospitalized with COVID-19 at Case Hospital, Uganda
    (Interdisciplinary Perspectives on Infectious Diseases, 2022-06-08) Apiyo, Mirriam; Olum, Ronald; Kabuye, Amina; Khainza, Betty; Amate, Anne M.; Byabashaija, Vittal; Nomujuni, Derrick; Sebbaale, Kato; Senfuka, Peter; Kazibwe, Simon; Sharma, Gurav; Davidson, Lindsay; Bongomin, Felix
    Data on clinical outcomes of patients hospitalized with coronavirus disease 2019 (COVID-19) in private health facilities in Uganda is scarce. We conducted a retrospective cohort study of patients hospitalized with COVID-19 at Case Hospital, Kampala, Uganda, between June 2020 and September 2021. Data of 160 participants (median age 45 years (interquartile range [IQR]: 37–57) and 63.5% male) was analyzed. Seventy-seven (48.1%) participants had non-severe, 18 (11.3%) severe, and 83 (51.9%) critical COVID 19 illness. In 62 participants with chest computed tomography £ndings, 54 (87%) had bilateral disease, with 22 (35%) having ground-glass opacities. e median duration of hospitalization was 5 days (IQR: 3–9 days). Overall, 18 (11.3%) participants died. Survival at 14 and 28 days was 89% and 72%, respectively. Factors strongly associated with all-cause mortality were as follows: age >50 years (odds ratio [OR]: 8.6, 95% con£dence interval [CI]: 1.1–69.2, and p 0.042), having at least 1 comorbidity (OR: 3.2, 95% CI: 1.1–8.9, and p 0.029), hypertension (OR: 3.2, 95% CI: 1.2–8.6, and p 0.024), diabetes mellitus (OR: 2.9, 95% CI: 1.0–8.5, andp 0.056), and oxygen saturation <92% (OR: 5.1, 95% CI: 1.8–14.4, and p 0.002). In this private health facility, mortality was about 1 in 10 patients, and more people presented with critical illness in the second wave of the pandemic, and most deaths occurred after 2 weeks of hospitalization.
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    Predictors of laboratory spontaneous tumour lysis syndrome in children with high-grade tumours in Uganda
    (Sage, 2021) Apiyo, Mirriam; Bongomin, Felix; Balagadde, Joyce; Mupere, Ezekiel; Ndeezi, Grace
    High-grade malignancy is endemic in sub-Saharan Africa and is prone to the spontaneous tumour lysis syndrome. However, data on spontaneous tumour lysis syndrome remain scanty in our setting. We sought to determine the prevalence and factors associated with laboratory spontaneous tumour lysis syndrome in children in Uganda. We conducted a cross-sectional study among children <18 years old with histologically confirmed high-grade malignancy between October 2013 and April 2014. Laboratory spontaneous tumour lysis syndrome was defined as the presence of 2 of each of hyperkalaemia, hypocalcaemia, hyperuricaemia and hyperphosphatemia prior to administration of chemo therapy when alternative diagnoses had been excluded. A p < 0.05 was considered statistically significant. Of 108 chil dren, of median age 7.7 years, where boys outnumbered girls 2:1, high-grade, malignancy included Burkitt’s lymphoma, acute lymphoblastic leukaemia, non-Hodgkin’s lymphoma, acute myeloid leukaemia and Burkitt’s leukaemia, with 14 suffering with laboratory spontaneous tumour lysis syndrome. Hypocalcaemia was its most common electrolyte imbal ance; and four children died prior to commencement of chemotherapy. Bulky disease, lactate dehydrogenase levels 500 iu/l and serum creatinine levels >1.2 mg/dl were associated with laboratory spontaneous tumour lysis syndrome. However, only bulky disease was significantly predictive of laboratory spontaneous tumour lysis syndrome. Such children would benefit from routine screening
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    Predictors of laboratory spontaneous tumour lysis syndrome in children with high-grade tumours in Uganda
    (Sage, 2021) Apiyo, Mirriam; Bongomin, Felix; Balagadde, Joyce; Mupere, Ezekiel; Ndeezi, Grace
    High-grade malignancy is endemic in sub-Saharan Africa and is prone to the spontaneous tumour lysis syndrome. However, data on spontaneous tumour lysis syndrome remain scanty in our setting. We sought to determine the prevalence and factors associated with laboratory spontaneous tumour lysis syndrome in children in Uganda. We conducted a cross-sectional study among children <18 years old with histologically confirmed high-grade malignancy between October 2013 and April 2014. Laboratory spontaneous tumour lysis syndrome was defined as the presence of 2 of each of hyperkalaemia, hypocalcaemia, hyperuricaemia and hyperphosphatemia prior to administration of chemo therapy when alternative diagnoses had been excluded. A p < 0.05 was considered statistically significant. Of 108 chil dren, of median age 7.7 years, where boys outnumbered girls 2:1, high-grade, malignancy included Burkitt’s lymphoma, acute lymphoblastic leukaemia, non-Hodgkin’s lymphoma, acute myeloid leukaemia and Burkitt’s leukaemia, with 14 suffering with laboratory spontaneous tumour lysis syndrome. Hypocalcaemia was its most common electrolyte imbal ance; and four children died prior to commencement of chemotherapy. Bulky disease, lactate dehydrogenase levels 500 iu/l and serum creatinine levels >1.2 mg/dl were associated with laboratory spontaneous tumour lysis syndrome. However, only bulky disease was significantly predictive of laboratory spontaneous tumour lysis syndrome. Such children would benefit from routine screening.