Prevalence and Predictors of CD4+ T-Lymphocytopenia Among HIV-Negative Tuberculosis Patients in Uganda
| dc.contributor.author | Baruch Baluku, Joseph | |
| dc.contributor.author | Musaazi, Joseph | |
| dc.contributor.author | Mulwana, Rose | |
| dc.contributor.author | Mugabo, Araali Robert | |
| dc.contributor.author | Bongomin, Felix | |
| dc.contributor.author | Katagira, Winceslaus | |
| dc.date.accessioned | 2023-11-23T15:33:39Z | |
| dc.date.available | 2023-11-23T15:33:39Z | |
| dc.date.issued | 2020 | |
| dc.description.abstract | Purpose: CD4+ T-lymphocytopenia is a risk for tuberculosis (TB) infection, reactivation and severe disease. We sought to determine the prevalence and predictors of CD4 T-lymphocytopenia among HIV-negative patients with bacteriologically confirmed TB in Uganda. Patients and Methods: Eligible participants were adult HIV-negative patients with bacter iologically confirmed TB at the National TB Treatment Centre in Uganda. CD4+ and CD8+ T-lymphocyte counts were determined by flow cytometry. We defined CD4+ T-lymphocytopenia as a CD4+ T-lymphocyte count of <418 cells/mm3 as per the population estimate for Ugandans. We performed logistic regression analysis to determine predictors of CD4+ T-lymphocytopenia. Results: We enrolled 216 participants whose mean age (standard deviation (±SD)) was 32.5 (±12.1) years, of whom 146 (67.6%) were males. The prevalence of CD4+ T-lymphocytopenia was 25% (54/216) (95% confidence interval (CI): 19.6–31.2%). Patients with anaemia (adjusted odds ratio (aOR): 3.83, 95% CI: 1.59–9.23, p = 0.003), weight loss (aOR: 3.61, 95% CI: 1.07–12.23, p = 0.039) and a low CD8+ T-cell count (aOR: 6.10, 95% CI: 2.68–13.89, p < 0.001) were more likely to have CD4+ T-lymphocytopenia while those with monocytosis (aOR: 0.35, 95% CI: 0.14–0.89, p = 0.028) were less likely to have CD4+ T-lymphocytopenia. Conclusion: There was a high prevalence of CD4+ T-lymphocytopenia among HIV negative TB patients. Patients with weight loss, anaemia and a low CD8+ count were more likely to have CD4+ T-lymphocytopenia while those with monocytosis were less likely to have CD4+ lymphocytopenia. The findings suggest that CD4+ lymphocytopenia is indicative of severe disease and globally impaired cell-mediated immune responses against TB | en_US |
| dc.identifier.citation | Baluku, J. B., Musaazi, J., Mulwana, R., Mugabo, A. R., Bongomin, F., & Katagira, W. (2020). Prevalence and predictors of CD4+ T-lymphocytopenia among HIV-negative tuberculosis patients in Uganda. Research and Reports in Tropical Medicine, 45-51. | en_US |
| dc.identifier.other | http://doi.org/10.2147/RRTM.S252550 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.14270/344 | |
| dc.language.iso | en | en_US |
| dc.publisher | Taylor & Francis | en_US |
| dc.subject | HIV negative, | en_US |
| dc.subject | tuberculosis, | en_US |
| dc.subject | CD4+, | en_US |
| dc.subject | CD8+, | en_US |
| dc.subject | lymphoctyopenia, | en_US |
| dc.subject | monocytosis, | en_US |
| dc.subject | weight loss, | en_US |
| dc.subject | anaemia | en_US |
| dc.title | Prevalence and Predictors of CD4+ T-Lymphocytopenia Among HIV-Negative Tuberculosis Patients in Uganda | en_US |
| dc.type | Article | en_US |