New Biologically Active Compounds from 1, 3-Diketones
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Date
2011-06-07
Journal Title
Journal ISSN
Volume Title
Publisher
Research Journal of Chemical Sciences
Abstract
The ready availability of cyclohexanones and the enhanced reactivity at their α-positions render them
starting materials of choice in the present study. The synthesis of new compounds of antimicrobial
activity was undertaken by the coupling of aromatic amines with 5,5-dimethyl cyclohexan-1,3-dione
(dimedone). The products were refluxed with N–benzyl-N-phenylhydrazine in acetic acid. The structures
of the products were elucidated using micro- and IR-spectral analyses. They were confirmed using 1H
NMR at 60MHz and TMS as internal standard. The diketone derivatives were tested for their biological
activity against gram-positive Cocci and Bacilli, and gram-negative Bacilli. The study showed that the
derivatives gave a wide range of activity from inactive to highly active, which proves it to be of fresh
pharmaceutical interest.
Key words: Dimedone, Antimicrobial activity, Gram-positive Cocci and Bacilli, Gram-negative Bacilli
Description
Keywords
Dimedone, Antimicrobial activity, Gram-positive Cocci and Bacilli, Gram-negative Bacilli
Citation
Mulongo, G., Mbabazi, J., Odongkara, B., Twinomuhwezi, H., & Mpango, G. B. (2011). New biologically active compounds from 1, 3-diketones.