New Biologically Active Compounds from 1, 3-Diketones

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dc.contributor.authorGeorge, Mulongo
dc.contributor.authorJolocam, Mbabazi
dc.contributor.authorOdongkara, B.
dc.contributor.authorTwinomuhwezi, H
dc.contributor.authorMpango, G.B.
dc.date.accessioned2026-06-17T10:29:01Z
dc.date.available2026-06-17T10:29:01Z
dc.date.issued2011-06-07
dc.description.abstractThe ready availability of cyclohexanones and the enhanced reactivity at their α-positions render them starting materials of choice in the present study. The synthesis of new compounds of antimicrobial activity was undertaken by the coupling of aromatic amines with 5,5-dimethyl cyclohexan-1,3-dione (dimedone). The products were refluxed with N–benzyl-N-phenylhydrazine in acetic acid. The structures of the products were elucidated using micro- and IR-spectral analyses. They were confirmed using 1H NMR at 60MHz and TMS as internal standard. The diketone derivatives were tested for their biological activity against gram-positive Cocci and Bacilli, and gram-negative Bacilli. The study showed that the derivatives gave a wide range of activity from inactive to highly active, which proves it to be of fresh pharmaceutical interest. Key words: Dimedone, Antimicrobial activity, Gram-positive Cocci and Bacilli, Gram-negative Bacilli
dc.identifier.citationMulongo, G., Mbabazi, J., Odongkara, B., Twinomuhwezi, H., & Mpango, G. B. (2011). New biologically active compounds from 1, 3-diketones.
dc.identifier.issn2231-606X
dc.identifier.urihttp://hdl.handle.net/20.500.14270/847
dc.language.isoen
dc.publisherResearch Journal of Chemical Sciences
dc.subjectDimedone
dc.subjectAntimicrobial activity
dc.subjectGram-positive Cocci and Bacilli
dc.subjectGram-negative Bacilli
dc.titleNew Biologically Active Compounds from 1, 3-Diketones
dc.typeArticle

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